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重组人源BAFFR蛋白

【货号】IRP020A 【蛋白名称】 重组人源BAFFR蛋白
【基因序列号/表达区域】Q96RJ3/7-71AA 【标签位置】C端Human-Fc Tag
【酶切位点】肠激酶 【包装规格】100μg/管

BAFF受体(B细胞活化因子受体,BAFF-R),也称为肿瘤坏死因子受体超家族成员13C(TNFRSF13C)CD268抗原。B淋巴瘤细胞的增殖转移受BAFF信号通路的调节,而BAFF-R作为BAFF信号通路的关键信号分子,在淋巴瘤细胞的增殖中起重要作用【1,2】。研究显示,BAFF-R 不仅表达于成熟的淋巴细胞,而且见于淋巴瘤细胞表面,在刺激B 淋巴瘤细胞增殖、避免B淋巴细胞凋亡等方面发挥重要作用,是研究相关疾病的重要潜在靶点【3-5】。目前,针对BAFF-R的抗体药开发已经进入临床三期。

产品名:重组人源BAFFR蛋白

物种:人源

基因序列号:Q96RJ3

标签:Human-Fc Tag

标签位点:C

酶切位点:肠激酶

表达区域:胞外段7-71AA

宿主细胞:CHO

纯度:>90%

纯化方式:Protein A

保存体系:PBS+20%甘油

储存条件:-80℃


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图示:左图Lane M为 protein MW marker,Lane 1为 15ug BAFFR-Fc蛋白;

右图为流式检测BAFFR-Fc蛋白与过表达 BAFFR-CAR的293T结合情况



参考资料:

1. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors

2. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

4. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

5. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL