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BAFF-R单链抗体

【货号】IAB017A 【抗体名称】 BAFF-R单链抗体
【抗体亚型】human IgG1 【用途】流式检测
【包装规格】100μg/管 【运输方式】-20°C运输

BAFF受体(B细胞活化因子受体,BAFF-R),也称为肿瘤坏死因子受体超家族成员13C(TNFRSF13C)CD268抗原。B淋巴瘤细胞的增殖转移受BAFF信号通路的调节,而BAFF-R作为BAFF信号通路的关键信号分子,在淋巴瘤细胞的增殖中起重要作用【1,2】。研究显示,BAFF-R 不仅表达于成熟的淋巴细胞,而且见于淋巴瘤细胞表面,在刺激B 淋巴瘤细胞增殖、避免B淋巴细胞凋亡等方面发挥重要作用,是研究相关疾病的重要潜在靶点【3-5】。目前,针对BAFF-R的抗体药开发已经进入临床三期。

本品为BAFF-R单链抗体,可用于过表达BAFF-R细胞株的流式检测或BAFF-R重组蛋白的活性检测。

产品名:BAFF-R单链抗体

反应性:human

浓度:1μg/μL

分析仪器:流式细胞仪

纯化方式:亲和层析

保存体系:PBS,pH 7.4,20%甘油

储存条件:-20°C冰箱,避免反复冻融


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图示说明:左图lane Mprotein MW marker,Lane 1 10ug BAFF-R单链抗体;右图为流式检测CHO-BAFF-R重组细胞表面BAFF-R的表达


参考资料:

1. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors

2. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

4. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

5. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL


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